Homocysteine, vitamins, and vascular disease prevention
نویسندگان
چکیده
منابع مشابه
Homocysteine, vitamins, and cardiovascular disease.
The significance of any association between cardiovascular disease and circulating homocysteine concentrations is attracting considerable attention. The normal activities of the transsulfuration and remethylation pathways maintain intracellular homocysteine levels within a narrow range, and the controlled release of homocysteine into blood results in blood measurements that provide an accurate ...
متن کاملLowering homocysteine with folic acid and B vitamins did not prevent vascular events in vascular disease.
M e t h o d s Design: Randomized placebo-controlled trial (Heart Outcomes Prevention Evaluation [HOPE] 2 trial). Allocation: Concealed.* Blinding: Blinded {clinicians, patients, data collectors, outcome assessors, and data analysts}†.* Follow-up period: Mean 5 years. Setting: 145 centers in 13 countries (Canada, United States, Brazil, western Europe, and Slovakia). Patients: 5522 patients ≥ 55 ...
متن کاملHomocysteine and vitamins in cardiovascular disease.
On the basis of recent retrospective and prospective studies, it is now widely accepted that increased total plasma homocysteine is a risk factor for cardiovascular disease. Impaired enzyme function as a result of genetic mutation or deficiency of the essential B vitamins folic acid, B12, and B6 can lead to hyperhomocysteinemia. Oxidized forms of homocysteine account for 98-99% of total plasma ...
متن کاملHomocysteine and vascular disease.
For more than 20 years, moderately raised concentrations of total homocysteine (tHcy) have been associated with an increased risk of atherothrombotic vascular events but only recently has evidence mounted to suggest that the association may be causal. The association is independent of other factors, it is fairly consistent across many studies, it is strong and dose-related, and it is biological...
متن کاملHomocysteine and vascular disease.
In my experience the largest individual group of sufferers from recurrent and especially incessant pericarditis have been those without recurrent effusions who are presumed, though rarely firmly demonstrated (as here), to have an immunopathy, and especially those who are ‘steroid hooked’. Indeed, there is some evidence that corticosteroid treatment has been necessary to initiate the cycle of re...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2007
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/86.5.1563s